Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling
نویسندگان
چکیده
منابع مشابه
Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling.
Platelet-derived growth factor receptor β (PDGFRβ) is a receptor tyrosine kinase which upon activation by PDGF-BB stimulates cell proliferation, migration and angiogenesis. Ligand binding induces intracellular signaling cascades but also internalization of the receptor, eventually resulting in its lysosomal degradation. However, endocytic trafficking of receptors often modulates their downstrea...
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Platelet-derived growth factor (PDGF)-D is a PDGF receptor β (PDGFRβ)-specific ligand implicated in a number of pathological conditions, such as cardiovascular disease and cancer, but its biological function remains incompletely understood. In this study, we demonstrate that PDGF-D binds directly to neuropilin 1 (NRP1), in a manner that requires the PDGF-D C-terminal Arg residue. Stimulation wi...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2016
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.191213